Sareum's TYK2/JAK1 reclinical development candidate molecule, SDC-1802, demonstrates high selectivity for TYK2 and JAK1 kinases (particularly over related JAK2 and JAK3). SDC-1802 shows compelling efficacy in blocking cancer cell proliferation in cellular and disease models of T-cell acute lymphoblastic leukaemia (T-ALL) and B-cell lymphoma, the potential for once-daily oral dosing and a good early safety profile. In addition, Sareum has generated encouraging evidence to suggest that these molecules can function as cancer immunotherapy by modulating the host’s immune system to block tumour cell proliferation in disease models of certain kidney, colon, skin and pancreatic cancers.
Sareum intends to progress SDC-1802 into preclinical development (and pending satisfactory progress) into human clinical trials which could begin in 2020.
Sareum is also advancing SDC-1801 as a distinct dual TYK2/JAK1 inhibitor for the potential treatment of autoimmune diseases, including psoriasis, rheumatoid arthritis, inflammatory bowel disease and lupus. SDC-1802 also has the potential to act as a back-up molecule for these autoimmune indications.
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