January 17, 2006, Oss, The Netherlands, and Cambridge, UK - Organon, the human health care business unit of Akzo Nobel and Sareum Holdings plc, the specialist structure-based drug discovery and services business, today announced a collaborative research agreement.
The aim of this collaboration, in which Sareum will potentially dedicate a multi-disciplinary research team for over one year, is to generate lead chemical series for development by Organon into novel therapies for autoimmune diseases such as rheumatoid arthritis.
Sareum will endeavor to determine the three-dimensional structures of two of the Organon autoimmune disease protein targets and then deploy its innovative Template Screening method to identify novel compounds suitable for optimisation into lead drug candidates, using its automated medicinal chemistry platform.
In return, Sareum will receive research fees and success milestone payments. Financial details were not disclosed.
This is the second announcement relating to the trading update issued by Sareum on 5th January 2006 where Sareum stated that it had entered into several collaborations in late December, one of which is with Organon.
Commenting on the agreement, Sareum's Chief Executive Officer, Dr Tim Mitchell, said: "We are delighted that Organon has chosen Sareum as their partner in drug lead identification and optimisation. This is the largest collaboration we have signed to date, and brings together our expertise in protein structure determination, Template Screening and automated chemistry. We look forward to successfully identifying novel drug leads for this important therapeutic area."
Dr David Nicholson, Executive Vice President Global Research, Organon International Inc. added: "This collaboration with Sareum fits very well with our ambitions of expanding the breadth and depth of our research programs. Access to new technologies and the focus on new therapeutic areas such as immunology are important building blocks to accomplish these ambitions. We believe that expanded research activities through partnerships are critical to fueling our future pipeline."
For further information:
Organon +31 412 66 54 40
Monique Mols, Director Media Relations firstname.lastname@example.org
Buchanan Communications 020 7466 5000
Tim Anderson, Mark Court, Mary-Jane Johnson
Notes for editors:
About Sareum Holdings plc
Sareum Holdings plc (AIM: SAR) is a specialist structure based drug discovery and services business headquartered in Cambridge, UK. The Company was formed in August 2003 to discover new drugs for the treatment of cancer and to provide a range of drug discovery services to the pharmaceutical industry. Sareum's unique approach aims to halve the time it takes to discover new drug candidates.
Sareum provides its specialist drug discovery capabilities to partners in the pharmaceutical and biotechnology industries. The Company aims to successfully deliver: Programmes for complete gene-to-candidate structure-based discovery; projects to accelerate or improve the productivity of specific activities; and drug candidates for licensing at the Phase I or Phase II clinical trials stage.
For further information, please visit www.sareum.co.uk.
Organon - with shared head offices in Roseland, NJ, USA and Oss, The Netherlands - creates, manufactures and markets prescription medicines that improve the health and quality of human life. Through a combination of independent growth and business partnerships, Organon strives to remain or become one of the leading pharmaceutical companies in each of its core therapeutic fields: gynecology, fertility, neuroscience and anesthesia. Organon products are sold in over 100 countries, of which more than 60 have an Organon subsidiary. Organon is the human health care business unit of Akzo Nobel.
For further information, please visit www.organon.com.
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