24 April 2008




(“Sareum” or “the Company”)

Notification of Shareholder Interest

Sareum Holdings plc (AIM: SAR), the specialist structure-based drug discovery business, is pleased to announce that it was informed on 23 April 2008 that Mr Joseph Edward Craven has purchased 14,200,000 Sareum ordinary shares of 0.025p as part of the placing announced on 14 April, 2008. Mr Craven now holds 38,000,000 Sareum ordinary shares representing 4.6 per cent of the Company's total voting rights. 

Commenting on the announcement, Sareum’s Chief Executive Officer, Dr Tim Mitchell, said: “We are very pleased that Mr Craven has chosen to increase his shareholding in Sareum.”


Mr Joseph Craven added: “I have been an investor in Sareum since 2005 and have great confidence in the Company’s management team and long term strategy.  I am pleased to be increasing my holding in this business.”

For further information:

Sareum Holdings plc

01223 497700

Tim Mitchell, Chief Executive Officer


Buchanan Communications

020 7466 5000

Tim Anderson, Mary-Jane Johnson


Grant Thornton Corporate Finance

020 7383 5100

Philip Secrett, Colin Aaronson



About Sareum Holdings plc

Sareum Holdings plc is a structure-based drug discovery business headquartered in Cambridge, UK. The Company was formed in August 2003 to discover new drugs for the treatment of cancer.  Sareum's unique approach aims to halve the time it takes to discover new drug candidates.

A structure-based approach to drug discovery relies on knowledge of the three-dimensional structure of the proteins that cause disease.  Once the structure is known, potential drugs are designed to 'lock-in' to the protein with the aim of reversing or arresting a disease's progression.  Knowledge of the structure of the potential drugs and how they 'lock-in' to their target protein assists greatly in the development of high-quality drug candidates. Determining structure is a complex task and requires leading-edge equipment and experienced staff.  Sareum's approach to structure determination utilises its proprietary protein expression platform in order to produce multiple recombinant proteins that accelerate structure determination using x-ray crystallography.

Once the structure is determined, the Company's innovative fragment screening platform is used to identify novel chemical templates designed to interact with the target protein.  Sareum then uses its high-throughput medicinal chemistry platform to rapidly optimise these molecules and develop the most promising into potential drug candidates.

Sareum aims to successfully deliver drug candidates for licensing to larger pharmaceutical companies at the pre-clinical or early clinical trials stage. This is funded by provision of its specialist drug discovery capabilities to partners in the pharmaceutical and biotechnology industries.

Sareum joined the AIM market of the London Stock Exchange in October 2004 and trades under the symbol SAR.  For further information, please visit www.sareum.co.uk