News & Events - Publications & Patents

Patents related to Sareum programmes

Aryl Imidazole and Aryl Oxazole Carboxamides for Treating Multiple Sclerosis. WO2010055304

5-Amidothiazole Derivatives and Their Use. WO2010007389

Bicyclylaryl-arly-amine Compound and thier use. WO2009103966

Therapeutic Biarylamine Compounds and Their Use. WO2009044162

Therapeutic Tricyclic Compounds and Their Use. WO2009004329

Oxazole Tyrosine Kinase Inhibitors. WO2008139161

Compounds and Thier Use as Anti Cancer Agents. WO2008075007

Publications related to Sareum programmes

Design and Evaluation of 3,6-di(hetero)aryl imidazo[1,2-a]pyrazines as Inhibitors of Checkpoint and Other Kinases. Matthews, T.P., McHardy, T., Klair, S., Boxhall, K., Fisher, M., Cherry, M., Allen, C.E., Addison, G.J., Ellard, J., Aherne, G.W., Westwood, I.M, van Montfort, R., Garrett, M.D., Reader, J.C. & Collins, I., Bioorg & Med Chem Lett (2010), 20(14), 4045-4049. Abstract

The Preclinical Pharmacology and Therapeutic Activity of the Novel CHK1 Inhibitor SAR-020106. Walton, M.I., Eve, P.D., Hayes, A., Valenti, M., De Haven Brandon, A., Box, G., Boxall, K.J., Aherne, G.W., Eccles, S.A., Raynauld, F.I., Williams, D.H., Reader, J.C., Collins, I., Garrett, M.D., Mol Cancer Ther (2010), 9(1), 89-100. Abstract
Identification of Inhibitors of Checkpoint Kinase 1 through Template Screening. Matthews, T.P., Klair, S., Burns, S., Boxall, K., Cherry, M., Fisher, M., Westwood, I.M., Walton, M.I., McHardy, T., Kwai-Ming, J.C., Van Montfort, R., Williams, D., Aherne, G.W., Garrett, M.D., Reader, J and Collins, I, J Medicinal Chemistry (2009), 52(15), 4810-4819. Abstract
Identification and Structure-guided Optimisation of Novel Inhibitors of Checkpoint Kinase 1 (Chk1) through Combined Biochemical and Crystallographic Screening. Reader, J., Williams, D., Klair, S., Cherry, M., Fisher, M., Scanlon, J., Piton, N., Addison, G., Lamers, M., et al. AACR Annual Meeting, San Diego, CA, Apr 12-16, 2008. Download PDF

Publications related to Sareum expertise

Introduction to Fragment-based Drug Discovery, T Mitchell & M Cherry in “Fragment-Based Drug Discovery: Practical Aspects”, E.R. Zartler & M.J. Shapiro, Eds, John Wiley & Sons (2008). Buy at Amazon

Fragment-Based Drug Design, Tim Mitchell, MedChem News (Japan), (2007), 1, 8-15
Finding protein kinase hits using structural information. Cherry, M., Reader, J. and Williams, D.H. Prog. Med. Chem., (2006). 44, 1-63.
Fragment-Based Drug Design, Mitchell, T. and Cherry, M. Innovations in Pharmaceutical Technology, (2005). 16, 34-36. Download PDF
The design of a new potent and selective ligand for the BRS3 receptor. Boyle, R.G., Humphries, J., Mitchell, T., Showell, G.A., Iijima, H., Shimada, H., Arai, T., Ueno, H., Usui, H., Sakaki, T., Wada, E. and Wada, K. J Peptide Research, (2005). 11(3), 136-141.
Automation in medicinal chemistry. Reader, John C. Current Topics in Medicinal Chemistry, (2004), 4(7), 671-686.
Solid phase synthesis of tetrahydro-1,4-benzodiazepin-2-ones. Hone, Neal D.; Wilson, William; Reader, John C. Tetrahedron Letters, (2003). 44(46), 8493-8495.
Solid-phase synthesis of dibenzoxazepinones. Hone, Neal D., Salter, James I., Reader, John C. Tetrahedron Letters, (2003). 44(44), 8169-8172.
Reusable resin plug-bound palladium catalysts for organic synthesis. Atrash, B., Reader, J. and Bradley, M. Tetrahedron Letters, (2003). 44(25), 4779-4782.
Descriptors, Physical Properties and Drug-Likedness. Brüstle, M., Beck, B., Schindler, T., King, W., Mitchell, T. and T. Clark, T. J. Med. Chem., (2002). 45(16), 3345-3355.
Latest developments in crystallography and structure-based design of protein kinase inhibitors as drug candidates. Williams, D.H. and Mitchell T. Curr Opin. Pharmacology, (2002). 2, 567-573.
Design, Synthesis, and Biological Evaluation of a Library of 1-(2-Thiazolyl)-5-(trifluoromethyl)pyrazole-4-carboxamides. Donohue, B.A., Michelotti, E.L., Reader, J.C., Reader, V., Stirling, M. and Tice, C.M. Journal of Combinatorial Chemistry, (2002). 4(1), 23-32.
Design Strategies for building drug-like chemical libraries. Mitchell, T. & Showell, G. Curr. Opin. Drug Disc. Dev., (2001). 4(3), 314-318.
Revolutionizing resin handling for combinatorial synthesis. Atrash, B., Bradley, M., Kobylecki, R., Cowell, D. and Reader, J. Angewandte Chemie, International Edition, (2001). 40(5), 938-941.